South African study offers hope against drug-resistant TB

By Ashleigh Furlong and Nathan Geffen    

The results of a study led by South African researcher Dr Francesca Conradie offers hope for patients with strains of tuberculosis (TB) that have been extremely difficult to treat. Conradie presented the findings of the NIX-TB trial in Seattle [last week] at the Conference on Retroviruses and Opportunistic Infections (CROI), the most important annual HIV science meeting. The trial was sponsored by the TB Alliance, a non-profit organisation.

Drug-resistant tuberculosis (TB) is a serious threat to public health. While most people with TB can be cured within six months, some strains of the disease are very difficult to treat. These are called Multi-Drug Resistant (MDR) TB and — when hardly any drugs are effective — Extensively Drug Resistant (XDR) TB. In the National Institute for Communicable Diseases’s latest survey on drug-resistant TB, conducted between 2012 and 2014, 2.8% of TB cases in South Africa were MDR-TB. One in every 20 patients with MDR-TB had XDR-TB. (TB in people with HIV is the biggest single cause of death in South Africa.)

Until now patients with XDR-TB have been treated with a large cocktail of drugs for 18 to 24 months, often with poor outcomes and terrible side effects. In the NIX-TB trial results nearly all of the XDR and MDR TB patients who completed treatment and had a six month follow up have remained disease free.

Conradie explained that “there is no current standard of care” for patients with XDR TB who have “limited options for treatment”. For these patients mortality rates can reach as high as 75% she said. “What we do, is we try and find out as many drugs, either from history or drug sensitivity analysis, and then throw them at the patients,” she said.

72 patients were recruited from April 2015, with 65% of the patients having XDR-TB. The remainder had MDR-TB and were either not responding to treatment or they could not tolerate the side-effects of their treatment. Just over half were HIV-positive. 40 patients have completed the six month long trial and 31 have had their six month follow up. Of these 31 patients, only one has relapsed and another has been re-infected with TB. During the early stages of the trial four people died. They all had advanced stages of TB with most of the deaths being related to TB that had spread from the lungs to other parts of the body.

Conradie called the results “encouraging in terms of efficacy and safety”. Notably, no patients withdrew from the trial due to drug toxicity and no patients had to extend their treatment after the initial six months. The study is set to expand to another site in eThekwini as well as other sites outside of South Africa.

This article was published by and first appeared on, on 20 February 2017.

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